https://www.ceesdekker.net - An Overview

https://www.ceesdekker.net - An Overview

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Spatial structure facilitates cooperation in a social dilemma: empirical evidence from the bacterial Group

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Being a individual, I have the biblical assignment to investigate and use anything in generation for the benefit of my neighbour. I usually do not practical experience any conflict between faith and science. On the contrary, my faith stimulates me to perform science, being open up-minded in the world.’

2007, initially real-time detection of strand exchange in homologous recombination by RecA; discovery of the small persistence length of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes

This yielded a breakthrough. Inside only some months, we had been able to measure transportation by means of an individual solitary-walled carbon nanotube. According to very low-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technological know-how using an Lively analysis lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were real quantum wires with pretty extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.

The coiled-coil of your human Rad50 DNA mend protein includes unique segments of enhanced flexibility

We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which assess the basic part of spatial confinement in the molecular and cellular degree. Our assignments involve the subsequent:

Nanopores represent an elegant and versatile tool to evaluate one molecules. We investigate novel detection modes with good-point out nanopores and many tips on how to evaluate proteins with nanopores. Jobs encompass the subsequent:

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There was just one trouble though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers were really not this sort of excellent conductors, which was relatively disappointing. We Consequently broadened our watch to test to search out additional promising molecules.

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Cees Dekker is Distinguished College Professor at TU Delft. Experienced for a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes from the nineties. Considering that 2000, he cees dekker moved to solitary-molecule biophysics and nanobiology. His existing analysis focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, in particular SMC motor protein; and (iii) building a dwelling artificial mobile from lifeless molecules. Dekker is really an elected member with the KNAW and fellow on the APS along with the IOP.

Allow’s 1st glance again for the time being if you chose to change your emphasis from superconductivity and nanotubes to biology at the conclusion of the nineties.

Solid-state nanopores have verified to get a amazingly multipurpose probe for one-molecule Examination of DNA. I will explain a few of our recent conclusions – especially DNA knots – in addition to our endeavours to grow the capabilities of stable-condition nanopores even further, from the route of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.